Protective effects of LEM against hypoxic-ischemic injury

Josai University

[Details]
After inoculating mice with a powdered feed mixed with LEM, a double ligature was performed on the right carotid artery, then the extent of brain damage caused by hypoxic gas was evaluated using infarct volume measurements.
 
[Results]
In the control group, infarction formed over a broad range, including the hippocampus and cortex, while cerebral infarction formation in the LEM group was restricted to one area, with a significant decrease in cerebral infarction volume of 50% to 70%, depending on the concentration of LEM.

Influence on multiplication of influenza A virus - Reducing the viral replication process

It was examined whether LEM has an effect of reducing the influenza viral replication process. Cells were namely infected with influenza A virus, and then LEM solution of a specified concentration was added to the infected cells. The expansion of plaques was tested through the plaque assay. The results showed that the plaques were LEM concentration-dependently reduced in size, suggesting the effect of reducing the influenza viral replication process, and of reducing multiplication as a result.