Therapy for hepatitis B patients using LEM

National Hospital Organization Kokura Medical Center

[Details]
6 grams of LEM were administered daily to 40 HBeAg-positive patients for at least four months, who were investigated continuously using serum biochemical tests and  HBV blood markers.
 
[Patient profiles]
19 patients with chronic active hepatitis, 8 patients with chronic inactive hepatitis, and 13 patients clinically diagnosed with chronic hepatitis B
 
[Results]
As for HBV markers, DNA polymerase activity decreased dramatically.
Out of the 40 patients, 17 had their serum HBe-antigen turn negative, and among these 10 a positive reaction in HBe-antibodies was seen, with seroconversion rates of 25%.
Among serum biochemical tests, GOT, GPT, and ZTT decreased significantly.
Aside from one patient’s complaint of abdominal bloating and loose stools during administration, no serious side effects were observed.