The effects of LEM on antibody production and immune-mediated hepatic cell injury

Osaka City University、Tohoku University

[Details]
Hepatic cell damage was induced in vitro through ADCC (Antibody-dependent cell-mediated cytotoxicity) response and activated macrophage (Mφ), then the effects of LEM on these was investigated.
 
[Results]
Adding ADCC response and activated Mφ to an isolated liver cell culture significantly reduced protein synthesis.
When liver cells were treated with LEM prior to exposure to these reactions, this decline in protein synthesis was significantly reduced.
This suggests that LEM reduces immune-mediated liver cell injury and has a protective effect on liver cells.