Clinical study on the prevention of recurrence of endometrial cancer post-surgery by administering LEM

Keiju Medical Center

[Details]
This study conducted three courses of monthly dosing of carboplatin + endoxan + adria + mycin in 13 patients with endometrial cancer (aged 61.2 ± 11.4 years) post hysterectomy.Patients were given 6 grams of LEM daily (3 grams twice a day) from the second week post-surgery for 22.5 ± 13.5 months, and were then examined for recurrence every two months afterward using vaginal cuff smears, tumor markers, ultrasound, and CT scans. Furthermore, those found to have signs of recurrence were checked every month.
　
[Results]
For one patient, CA-19-9 levels rose three months after being discharged from the hospital but began decreasing when the LEM dose was increased to 9 grams per day (3 grams 3 times a day).This suggests that LEM inhibits recurrence in patients with postoperative endometrial cancer.

Influence on multiplication of influenza A virus - Reducing the viral replication process

It was examined whether LEM has an effect of reducing the influenza viral replication process. Cells were namely infected with influenza A virus, and then LEM solution of a specified concentration was added to the infected cells. The expansion of plaques was tested through the plaque assay. The results showed that the plaques were LEM concentration-dependently reduced in size, suggesting the effect of reducing the influenza viral replication process, and of reducing multiplication as a result.